Research in our Lab

Our laboratory is interested in understanding the role of Epigenome in somatic mammalian cells. Our research mainly focuses on Polycomb Group Proteins (PcG), noncoding RNA, repeat elements and chromatin associated RNAi components. 


Current Research

PcG proteins play a fundamental role in maintaining early determined tissue specific genetic programs by controling various levels of chromosome structure and topological organization. However, far from being a rigid platform, cell memory mechanisms ensure the degree of competence and flexibility that enable cells and tissues to respond to environmental stimuli.
​Repetitive elements constitute the 45% of the human genome, comprising various classes of DNA elements including Long and Short Interspersed Nuclear Elements (LINEs and SINEs, respectively 20% and 13% of the genome, potentially a major source of genetic variations in human cells. L1 and SINE elements are classified as retrotransposable elements (TEs) as they retain or have acquired the capability to move around in the host genome, via an RNA-mediated mechanism or recombination. ​
Noncoding RNA plays an important role in epigenome structure and gene regulation.  However, little is known about chromatin protein complexes and the mechanisms that regulate ncRNA function.