Current Research

Role of nuclear RNAi components in cell differentiation and adaptation



​Noncoding RNA plays an important role in epigenome structure and gene regulation.  However, little is known about chromatin protein complexes and the mechanisms that regulate ncRNA function. Our previous work performed in Drosophila revealed an unexpected functional link between RNAi components at promoters of active genes, Pol II pausing and stress response (Cernilogar et al, Nature 2011).​​

We are now interested in investigating the role of RNAi components in mammalian cells and in particular in nuclear architecture dynamics in somatic cell response to environmental stress. To this aim we combine protein complex biochemistry, genomics and imaging.