Our Ezh1 Paper on Nature Structure and Molecular Biology is out

Our Ezh1 Paper on Nature Structure and Molecular Biology is out

5/10/2017
The histone methyltransferase Polycomb repressive complex 2 (PRC2) represses transcription by catalysing the trimethylation of histone H3 Lys27 (H3K27me3). The complex can contain either of two different catalytic subunits: EZH1, which is expressed mostly in differentiated, postmitotic cells; or EZH2, which is expressed predominantly in proliferating cells. The function of EZH1-containing PRC2 (PRC2-EZH1) in adult postmitotic tissues is unclear. Studying postmitotic muscle cells, Bodega et al. identified a cytosolic isoform of EZH1 that inhibits PRC2-EZH1 activity, thereby enabling the expression of muscle-specific genes. In conditions of muscle atrophy, the inhibition is alleviated and muscle-specific genes are repressed by PRC2-EZH1.